A new type of bacteria called tricontid valve has been discovered in the gut of a man with chronic constipation, leading to the development of a treatment that could potentially be used to treat the condition.
Key points:Researchers have found that when the bacteria enters the small intestine, it produces a toxin that kills most bacteriaIt could potentially help treat chronic constipated people who have an inflammatory bowel disease or a leaky gutIt could also be used in the treatment of colitis or other chronic conditionsThere’s currently no treatment for chronic constipsated people without a leak of bowel secretionsThe research was led by the Queensland University of Technology and was published in the Australian Medical Association Journal.
The researchers looked at the bacteria that were present in the human gut of the man and determined how often it entered the small intestines of his patients.
In the case of the two patients who had a leak in their small intestine, the bacteria produced toxins that were very effective in killing most bacteria, including some that normally cause diarrhoea.
The toxin produced by the bacteria in these two patients was very effective against the bacteria they were killing, the researchers found.
The team was able to isolate a particular toxin from the toxin produced in these bacteria, and they could then use it to treat constipation.
Dr Robert McBride, from the university’s Department of Pathobiology, said the team’s findings showed that the bacterial toxin was a powerful way to kill bacteria.
“It kills bacteria but it doesn’t kill all of them,” he said.
“If we have the right kind of bacteria in the right place in the body, it’s able to kill most of them.”
“If you can isolate and sequence the genes for killing specific types of bacteria, you can then identify which are causing inflammation, and which are not.”
Tricontid bacteria were also able to attack other types of bacterial cells, including those found in the lining of the small bowel.
“The researchers found that the bacteria could kill many types of cells and the toxin is able to be able to penetrate those cells, and then be able use it against other types,” Dr McBride said.
He said the toxin would have a high potency to kill even healthy, healthy cells, but he added that it would have to be administered via the gut and not the bloodstream.
“What we’re really interested in is what it’s going to do to healthy cells.
We want to understand how it’s doing that and how it affects healthy cells,” he explained.
The new study was carried out by the Department of Medical Research and Development at the Queensland Institute of Technology.
“Our research was focused on how these bacteria could enter the small intestinal tract and kill healthy cells but we were interested in other aspects of the process and were also interested in whether the toxin could kill cancer cells,” Dr John Jager, from QUT, said.
The research has been supported by the Australian Research Council and the Queensland Government.